Contraindicated. Cobicistat can be a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are linked to really serious and/or everyday living-threatening functions.ergotamine will boost the degree or result of tazemetostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track o… Read More